Autophagy in Health and Disease by Roberta A. Gottlieb

By Roberta A. Gottlieb

Autophagy in healthiness and Disease bargains an outline of the most recent examine in autophagy with a translational emphasis. This booklet takes clinical examine in autophagy a step extra and provides built-in content material with developments in autophagy from cellphone biology and biochemical study to medical remedies. an important reference for the bookshelf of scientific and medical researchers and scholars, Autophagy in future health and Disease provides prime quality, respected info on autophagy, permitting the reader easy accessibility to the main appropriate information.

  • Discusses present knowing of the jobs of autophagy in well-being and disease
  • Covers the history of autophagy, the improvement of instruments and therapeutics to degree and modulate autophagy, and autophagy in tissues and ailment processes

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Autophagy has been observed in hypertrophied myocardium30. Protein turnover is increased during hypertrophy, although in previous reports, autophagy was diminished in response to aortic stenosis12 and isoproterenol infusion31. Pressure overload is accompanied by an elevated rate of myocardial protein synthesis and cardiac hypertrophy32. In our experiments, pressure overload due to transverse aortic constriction (TAC) induced hypertrophy without cardiac dysfunction 1 week after TAC in wild-type mice33.

Stappenbeck TS, Rioux JD, Mizoguchi A, Saitoh T, Huett A, Darfeuille-Michaud A, et al. Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy 2011;7(4):355e74. 154. Xavier RJ, Huett A, Rioux JD. Autophagy as an important process in gut homeostasis and Crohn’s disease pathogenesis. Gut 2008;57(6):717e20. 155. Henckaerts L, Cleynen I, Brinar M, John JM, Van Steen K, Rutgeerts P, et al. Genetic variation in the autophagy gene ULK1 and risk of Crohn’s disease. Inflamm Bowel Dis 2011.

31. Pfeifer U, Fohr J, Wilhelm W, Dammrich J. Short-term inhibition of cardiac cellular autophagy by isoproterenol. J Mol Cell Cardiol 1987;19:1179e84. 32. Imamura T, McDermott PJ, Kent RL, Nagatsu M, Gt Cooper, Carabello BA. Acute changes in myosin heavy chain synthesis rate in pressure versus volume overload. Circ Res 1994;75:418e25. 33. Yamaguchi O, Higuchi Y, Hirotani S, Kashiwase K, Nakayama H, Hikoso S, et al. Targeted deletion of apoptosis signal-regulating kinase 1 attenuates left ventricular remodeling.

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