By J. Richard Smith, Giuseppe Del Priore, Robert L. Coleman, John M. Monaghan, John Curtin
Totally up to date and revised, the second one variation of An Atlas of Gynecologic Oncology provides a whole description of the investigative and surgeries performed by means of the gynecologic oncologist. Key good points of this significant textual content comprise:
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Subsequent investigation revealed that levels of serum prostasin were found to be higher in patients with ovarian cancer compared to controls with levels declining after surgery. 9%) for the same specificity (Mok et al. 2001). Osteopontin, another biomarker was similarly identified. Osteopontin expression was higher in tissue samples from patients with invasive and borderline ovarian cancer than benign tumors and normal ovaries. Plasma levels of Osteopontin were also significantly higher in patients with epithelial ovarian cancer compared to controls (Kim et al.
2000) and improved detection of recurrent disease, especially in those patients who had elevated TPS serum levels prior to therapy (Sliutz et al. 1995). The potential usefulness of CYFRA 21–1 as a tumor marker for ovarian malignancy needs to be explored further before any firm conclusions can be drawn (Hasholzner et al. 1994, Mazurek et al. 1998, Tempfer et al. 1998b, Gadducci et al. 2001). Kallikrein Kallikreins are a subgroup of serine proteases with diverse physiological functions. 4. Two members of the human kallikrein gene family, prostate-specific antigen and human kallikrein 2, have already found important clinical application as prostate cancer biomarkers.
In the adult, it is found in structures derived from celomic epithelia (the mesothelial cells of the pleura, pericardium and peritoneum) and in tubal, endometrial and endocervical epithelia. Curiously, the surface epithelia of normal fetal and adult ovaries do not express the determinant, except in inclusion cysts, areas of metaplasia and papillary excrescence (Kabawat et al. 1983). More recently, expression has been identified outside the female genital tract in epithelial cells of the lung, breast, conjunctiva and glandular epithelia of the prostate gland (Nap 1998).