By Praveen Ballabh MD
The sixteen articles during this factor draw at the services of across the world well-known specialists who've jointly supplied cross-cutting studies with a wide standpoint at the present nation of the sector. The authors have supplied succinct, up to date medical views and spotlight present controversies and destiny demanding situations. consequently, this factor is a state of the art compendium of this complicated and fast-moving box. through the factor, the reader is inspired to obtain a extra complete point of view by means of drawing connections among past and later articles which are thematically grouped round matters facing pathogenesis, analysis, and remedy. This factor underscores the very important significance of persisted help to motivate and nurture collaboration between clinicians and scientists.
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Additional resources for Advances in Neonatal Neurology, An Issue of Clinics in Perinatology, 1e
Dev Neuropsychol 2007;32(3):769–85. Robertson NJ, Tan S, Groenendaal F, et al. Which neuroprotective agents are ready for bench to bedside translation in the newborn infant? e4. Sherman L, Back S. A GAG reflex prevents repair of the damaged CNS. Trends Neurosci 2008;31(1):44–52. Miller SP, Ferriero DM. From selective vulnerability to connectivity: insights from newborn brain imaging. Trends Neurosci 2009;32(9):496–505. Ment LR, Hirtz D, Huppi PS. Imaging biomarkers of outcome in the developing preterm brain.
Volpe JJ. Brain injury in premature infants: a complex amalgam of destructive and developmental disturbances. Lancet Neurol 2009;8(1):110–24. 23 24 Back 147. Srinivasan L, Dutta R, Counsell SJ, et al. Quantification of deep gray matter in preterm infants at term-equivalent age using manual volumetry of 3-tesla magnetic resonance images. Pediatrics 2007;119(4):759–65. 148. Keunen K, Kersbergen KJ, Groenendaal F, et al. Brain tissue volumes in preterm infants: prematurity, perinatal risk factors and neurodevelopmental outcome: a systematic review.
Upper panel) Microscopic necrotic WMI. (A) Representative appearance of a focal hypointense (F-hypo) lesion seen on a T2-weighted image at 2 weeks after injury. Note the substantial difference in the F-hypo lesion relative to a diffuse gliotic lesion at 2 weeks, which appears more hyperintense (D-hyper). (B) A typical microscopic necrotic lesion defined by a discrete focus of immunohistochemical staining for reactive microglia and macrophages with Iba1 (red and inset) and a paucity of staining for astrocytes with glial fibrillary acidic protein (GFAP; green).